Methoxyphenyl Imidazolines as Potential Activators of p53

Methoxyphenyl Imidazolines as Potential Activators of p53

The use of p53-MDM2/X inhibitors is a prospective strategy in anti-cancer therapy for tumors with wild type p53 protein. In our study, new low-molecular-weight inhibitors of the p53-mdm2 interaction have been proposed. The two-step synthesis of the imidazoline core with subsequent modifications for...

Full description

Bibliographic Details
Main Authors: Daniil R. Bazanov, Nikolay V. Pervushin, Natalia A. Lozinskaya, Gelina S. Kopeina
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Medical Sciences Forum
Subjects:
p53
nutlin
mdm2
mdmx
imidazoline
Online Access:https://www.mdpi.com/2673-9992/14/1/100

Similar Items

Similar Items