Phenylalanine-Derived β-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity

Phenylalanine-Derived β-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity

Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca<sup>2+</sup> non-selective ion channel implicated in a variety of pathological conditions, including cancer, inflammatory and neuropathic pain. In previous works we identified a family of chiral, highly hydr...

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Bibliographic Details
Main Authors: María Ángeles Bonache, Pedro Juan Llabrés, Cristina Martín-Escura, Roberto De la Torre-Martínez, Alicia Medina-Peris, Laura Butrón, Isabel Gómez-Monterrey, Ana María Roa, Gregorio Fernández-Ballester, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
TRPM8
antagonists
β–lactams
absolute configuration
Ca<sup>2+</sup> microfluorimetry
Patch-Clamp
Online Access:https://www.mdpi.com/1422-0067/22/5/2370

Internet

https://www.mdpi.com/1422-0067/22/5/2370

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