TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy

TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy

Abstract Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 changes associated with Duchenne muscular dystrophy (DMD) are poorly understood, and it remains unclear how TAK1 regu...

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Bibliographic Details
Main Authors: Dengqiu Xu, Sijia Li, Lu Wang, Jingwei Jiang, Lei Zhao, Xiaofei Huang, Zeren Sun, Chunjie Li, Lixin Sun, Xihua Li, Zhenzhou Jiang, Luyong Zhang
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
TAK1
Duchenne muscular dystrophy
Fibrosis
Differentiation
Online Access:https://doi.org/10.1002/jcsm.12650

Internet

https://doi.org/10.1002/jcsm.12650

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