TAZ inhibition promotes IL-2-induced apoptosis of hepatocellular carcinoma cells by activating the JNK/F-actin/mitochondrial fission pathway

TAZ inhibition promotes IL-2-induced apoptosis of hepatocellular carcinoma cells by activating the JNK/F-actin/mitochondrial fission pathway

Abstract Background Cytokine-based cancer therapies have attracted a great deal of attention in recent years. Unfortunately, resistance to treatment limits the efficacy of these therapeutics. Therefore, the aim of our study was to explore the mechanism of IL-2-based therapy for hepatocellular carcin...

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Bibliographic Details
Main Authors: Kaihua Ji, Kaili Lin, Yan Wang, Liqing Du, Chang Xu, Ningning He, Jinhan Wang, Yang Liu, Qiang Liu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cancer Cell International
Subjects:
TAZ
IL-2
HepG2 cells
Mitochondrial damage
Apoptosis
Mitochondrial fission
Online Access:http://link.springer.com/article/10.1186/s12935-018-0615-y

Internet

http://link.springer.com/article/10.1186/s12935-018-0615-y

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