TwoStepCisMR: A Novel Method and R Package for Attenuating Bias in <i>cis</i>-Mendelian Randomization Analyses

TwoStepCisMR: A Novel Method and R Package for Attenuating Bias in <i>cis</i>-Mendelian Randomization Analyses

Mendelian randomisation (MR) is an increasingly popular method for strengthening causal inference in epidemiological studies. <i>cis</i>-MR in particular uses genetic variants in the gene region of a drug target protein as an instrumental variable to provide quasi-experimental evidence f...

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Bibliographic Details
Main Authors: Benjamin Woolf, Loukas Zagkos, Dipender Gill
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Genes
Subjects:
Mendelian randomisation
drug-target validation
sensitivity analyses
Online Access:https://www.mdpi.com/2073-4425/13/9/1541

Internet

https://www.mdpi.com/2073-4425/13/9/1541

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