Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins
Here, the authors provide cryo-EM structures of mature and immature Spondweni virus, defining the furin recognition site at high resolution, and identifying a lipid that binds E upon capsid maturation and is also present in Zika and Dengue virions.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21505-9 |