Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging

Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging

Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional <i>Alox</i> genes and the encoded enzymes share a high degree of amino acid conservation with their human orth...

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Bibliographic Details
Main Authors: Marjann Schäfer, Kumar R. Kakularam, Florian Reisch, Michael Rothe, Sabine Stehling, Dagmar Heydeck, Gerhard P. Püschel, Hartmut Kuhn
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
eicosanoids
lipid peroxidation
oxidative stress
polyenoic fatty acids
erythropoiesis
Online Access:https://www.mdpi.com/2227-9059/10/6/1379

Internet

https://www.mdpi.com/2227-9059/10/6/1379

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