Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Abstract Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the precise mechanisms of complement-med...

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Bibliographic Details
Main Authors: Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Acta Neuropathologica Communications
Subjects:
Complement
Membrane attack complex
Synapse loss
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s40478-022-01404-w

Internet

https://doi.org/10.1186/s40478-022-01404-w

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