Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process

Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process

Intracellular amyloid β peptide (Aβ) accumulation has drawn attention in relation to the pathophysiology of Alzheimer’s disease in addition to its extracellular deposition as senile plaque. Cellular uptake of extracellular Aβ is one of the possible mechanisms by which intracellular Aβ deposits form....

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Bibliographic Details
Main Authors: Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki Morino, Hirofumi Maruyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
amyloid – beta
HSPG
lipid raft
macropinocytosis
Rac1
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.804702/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.804702/full

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