Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

IgE is a critical component of the allergic response and therapeutic targeting can alleviate symptomology. Here the authors propose the combined use of Bifidobacterium longum and a FcεRIα extracellular domain linked to a IgD/IgG4 hybrid Fc domain fusion protein called IgETRAP and show reduction of m...

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Bibliographic Details
Main Authors: Seong Beom An, Bo-Gie Yang, Gyeonghui Jang, Do-Yeon Kim, Jiyoung Kim, Sung-Man Oh, Nahyun Oh, Sanghee Lee, Ji-Yeong Moon, Jeong-Ah Kim, Ji-Hyun Kim, Yoo-Jeong Song, Hye-Won Hyun, Jisoo Kim, Kyungwha Lee, Dajeong Lee, Min-Jung Kwak, Byung Kwon Kim, Young-Kyu Park, Chun-Pyo Hong, Jung Hwan Kim, Hye Seong Lim, Min Sook Ryu, Hyun-Tak Jin, Seung-Woo Lee, Yoon-Seok Chang, Hae-Sim Park, Young Chul Sung, Myoung Ho Jang
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33176-1

Internet

https://doi.org/10.1038/s41467-022-33176-1

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