Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors

Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors

Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse breast cancer subtype typified by the presence of p53 mutations (∼80%), elevated immune gene signatures and neoantigen expression, as well as the presence of tumor infiltrating lymphocytes (TILs). As these factors are hypo...

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Bibliographic Details
Main Authors: Erika J. Crosby, Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang, Cong-Xiao Liu, Pankaj Agarwal, Alan J. Korman, Michael A. Morse, Kenneth Gouin, Simon R. V. Knott, H. Kim Lyerly, Zachary C. Hartman
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
breast cancer
checkpoint blockade
immunomodulation
immune responses to cancer
tcr sequencing
triple-negative breast cancer
tumor antigens
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1421891

Internet

http://dx.doi.org/10.1080/2162402X.2017.1421891

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