Ectopic KIT copy number variation underlies impaired migration of primordial germ cells associated with gonadal hypoplasia in cattle (Bos taurus).

Ectopic KIT copy number variation underlies impaired migration of primordial germ cells associated with gonadal hypoplasia in cattle (Bos taurus).

Impaired migration of primordial germ cells during embryonic development causes hereditary gonadal hypoplasia in both sexes of Northern Finncattle and Swedish Mountain cattle. The affected gonads exhibit a lack of or, in rare cases, a reduced number of germ cells. Most affected animals present left-...

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Bibliographic Details
Main Authors: Heli Venhoranta, Hubert Pausch, Michal Wysocki, Izabela Szczerbal, Reetta Hänninen, Juhani Taponen, Pekka Uimari, Krzysztof Flisikowski, Hannes Lohi, Ruedi Fries, Marek Switonski, Magnus Andersson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3784456?pdf=render

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http://europepmc.org/articles/PMC3784456?pdf=render

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