Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

Abstract Disruption of intestinal epithelial functions is linked to Crohn disease (CD) pathogenesis. We identified a widespread reduction in the expression of long non-coding RNAs (lncRNAs) including LHFPL3-AS2 in the treatment-naïve CD ileum of the RISK pediatric cohort. We validated the reduction...

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Bibliographic Details
Main Authors: Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Marina BenShoshan, Haya Abbas-Egbariya, Rakefet Ben-Yishay, Liat Anafi, Camilla Avivi, Iris Barshack, Lee A. Denson, Yael Haberman
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47997-7

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https://doi.org/10.1038/s41598-023-47997-7

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