Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specific neutralizing antibody. The structure illustrates...

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Bibliographic Details
Main Authors: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
HIV-1
gp41
membrane fusion
LN01
4E10
2H10
Online Access:https://elifesciences.org/articles/65005

Internet

https://elifesciences.org/articles/65005

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