DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D
Type 1 diabetes (T1D) is an autoimmune disease that leads to insulin deficiency and hyperglycemia. Little is known about how this metabolic dysfunction, which substantially alters the internal environment, forces cells to adapt through epigenetic mechanisms. Consequently, the purpose of this work wa...
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MDPI AG
2020-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/1/13 |
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| author | Raúl F Pérez Juan Luis Fernandez-Morera Judit Romano-Garcia Edelmiro Menendez-Torre Elias Delgado-Alvarez Mario F Fraga Agustin F Fernandez |
| author_facet | Raúl F Pérez Juan Luis Fernandez-Morera Judit Romano-Garcia Edelmiro Menendez-Torre Elias Delgado-Alvarez Mario F Fraga Agustin F Fernandez |
| author_sort | Raúl F Pérez |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) is an autoimmune disease that leads to insulin deficiency and hyperglycemia. Little is known about how this metabolic dysfunction, which substantially alters the internal environment, forces cells to adapt through epigenetic mechanisms. Consequently, the purpose of this work was to study what changes occur in the epigenome of T1D patients after the onset of disease and in the context of poor metabolic control. We performed a genome-wide analysis of DNA methylation patterns in blood samples from 18 T1D patients with varying levels of metabolic control. We identified T1D-associated DNA methylation differences on more than 100 genes when compared with healthy controls. Interestingly, only T1D patients displaying poor glycemic control showed epigenetic age acceleration compared to healthy controls. The epigenetic alterations identified in this work make a valuable contribution to improving our understanding of T1D and to ensuring the appropriate management of the disease in relation to maintaining healthy aging. |
| first_indexed | 2024-03-10T13:47:48Z |
| format | Article |
| id | doaj.art-c1ffa90ce3e1458ca186a17ec340c38d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T13:47:48Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c1ffa90ce3e1458ca186a17ec340c38d2023-11-21T02:30:02ZengMDPI AGBiomedicines2227-90592020-12-01911310.3390/biomedicines9010013DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1DRaúl F Pérez0Juan Luis Fernandez-Morera1Judit Romano-Garcia2Edelmiro Menendez-Torre3Elias Delgado-Alvarez4Mario F Fraga5Agustin F Fernandez6Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, SpainNanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, SpainServicio de Anestesiologia y Reanimacion, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Asturias, SpainEndocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Asturias, SpainEndocrinology and Nutrition Department, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Asturias, SpainNanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, SpainNanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 33011 Oviedo, Asturias, SpainType 1 diabetes (T1D) is an autoimmune disease that leads to insulin deficiency and hyperglycemia. Little is known about how this metabolic dysfunction, which substantially alters the internal environment, forces cells to adapt through epigenetic mechanisms. Consequently, the purpose of this work was to study what changes occur in the epigenome of T1D patients after the onset of disease and in the context of poor metabolic control. We performed a genome-wide analysis of DNA methylation patterns in blood samples from 18 T1D patients with varying levels of metabolic control. We identified T1D-associated DNA methylation differences on more than 100 genes when compared with healthy controls. Interestingly, only T1D patients displaying poor glycemic control showed epigenetic age acceleration compared to healthy controls. The epigenetic alterations identified in this work make a valuable contribution to improving our understanding of T1D and to ensuring the appropriate management of the disease in relation to maintaining healthy aging.https://www.mdpi.com/2227-9059/9/1/13type 1 diabetesDNA methylationPhenoAgeepigenetic agingage accelerationmetabolic control |
| spellingShingle | Raúl F Pérez Juan Luis Fernandez-Morera Judit Romano-Garcia Edelmiro Menendez-Torre Elias Delgado-Alvarez Mario F Fraga Agustin F Fernandez DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D Biomedicines type 1 diabetes DNA methylation PhenoAge epigenetic aging age acceleration metabolic control |
| title | DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D |
| title_full | DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D |
| title_fullStr | DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D |
| title_full_unstemmed | DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D |
| title_short | DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D |
| title_sort | dna methylomes and epigenetic age acceleration associations with poor metabolic control in t1d |
| topic | type 1 diabetes DNA methylation PhenoAge epigenetic aging age acceleration metabolic control |
| url | https://www.mdpi.com/2227-9059/9/1/13 |
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