Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss

Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss

Abstract Background Chrysosplenetin is an O-methylated flavonol compound isolated from the plant Chamomilla recutita and Laggera pterodonta. The aim of our research is to evaluate the function of Chrysosplenetin on osteogenesis of human-derived bone marrow stromal cells (hBMSCs) and inhibition of es...

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Bibliographic Details
Main Authors: Guoju Hong, Xiaoming He, Yingshan Shen, Xiaojun Chen, Fang Yang, Peng Yang, Fengxiang Pang, Xiaorui Han, Wei He, Qiushi Wei
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Chrysosplenetin
BMSC
Osteoblast
Wnt/β-catenin
DKK1
Noggin
Online Access:http://link.springer.com/article/10.1186/s13287-019-1375-x

Internet

http://link.springer.com/article/10.1186/s13287-019-1375-x

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