Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

Drug repurposing offers an efficient approach to therapeutic development. In this study, our bioinformatic analysis first predicted an association between obesity and lansoprazole (LPZ), a commonly prescribed drug for gastrointestinal ulcers. We went on to show that LPZ treatment increased energy ex...

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Bibliographic Details
Main Authors: Yingting Wu, Jiaqi Xin, Xinyu Li, Ting Yang, Yi Liu, Yongsheng Zhao, Wen Xie, Mengxi Jiang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lansoprazole
Proton pump inhibitors
Adipose thermogenesis
Energy expenditure
Metabolic syndrome
PHOSPHO1 inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524000017

Internet

http://www.sciencedirect.com/science/article/pii/S2211383524000017

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