Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation

Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation

Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the intestinal tract with currently not well-understood pathogenesis. In addition to the involvement of immune cells, increasing studies show an important role for fibroblasts in the pathogenesis of IBD. Previous work showed tha...

Full description

Bibliographic Details
Main Authors: Zhou Zhou, Leonie G. Plug, Thiago A. Patente, Eveline S. M. de Jonge-Muller, Amir Abou Elmagd, Andrea E. van der Meulen-de Jong, Bart Everts, Marieke C. Barnhoorn, Lukas J. A. C. Hawinkels
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
PFKFB3
stromal cells
glycolysis
fibroblast
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.966067/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.966067/full

Similar Items