Exploring the Functions of Mutant p53 through <i>TP53</i> Knockout in HaCaT Keratinocytes

Exploring the Functions of Mutant p53 through <i>TP53</i> Knockout in HaCaT Keratinocytes

Approximately 50% of tumors carry mutations in <i>TP53</i>; thus, evaluation of the features of mutant p53 is crucial to understanding the mechanisms underlying cell transformation and tumor progression. HaCaT keratinocytes represent a valuable model for research in this area since they...

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Bibliographic Details
Main Authors: Daniil Romashin, Alexander Rusanov, Viktoriia Arzumanian, Alexandra Varshaver, Ekaterina Poverennaya, Igor Vakhrushev, Alexander Netrusov, Nataliya Luzgina
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Current Issues in Molecular Biology
Subjects:
<i>TP53</i>
p53
HaCaT
transcriptomics
gene knockout
Online Access:https://www.mdpi.com/1467-3045/46/2/94

Internet

https://www.mdpi.com/1467-3045/46/2/94

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