Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus macaques

Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus macaques

BackgroundCommonly used opioids, such as morphine have been implicated in augmented SIV/HIV persistence within the central nervous system (CNS). However, the extent of myeloid cell polarization and viral persistence in different brain regions remains unclear. Additionally, the additive effects of mo...

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Bibliographic Details
Main Authors: Omalla A. Olwenyi, Samuel D. Johnson, Mehdi Bidokhti, Vandana Thakur, Kabita Pandey, Michellie Thurman, Arpan Acharya, Srijayaprakash Uppada, Shannon Callen, Luis Giavedoni, Udaykumar Ranga, Shilpa J. Buch, Siddappa N. Byrareddy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Neuroscience
Subjects:
morphine
gut-brain axis
microbiome
microglia
SHIV
neurogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1001544/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.1001544/full

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