Insight into the conserved structural dynamics of the C-terminus of mammal PrPC identifies structural core and possible structural role of pharmacological chaperones

Insight into the conserved structural dynamics of the C-terminus of mammal PrPC identifies structural core and possible structural role of pharmacological chaperones

ABSTRACTMisfolding of the prion protein is central to prion disease aetiology. Although understanding the dynamics of the native fold helps to decipher the conformational conversion mechanism, a complete depiction of distal but coupled prion protein sites common across species is lacking. To fill th...

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Hlavní autoři: Patricia Soto, Garrett M. Gloeb, Kaitlin A. Tsuchida, Austin A. Charles, Noah M. Greenwood, Heidi Hendrickson
Médium: Článek
Jazyk:English
Vydáno: Taylor & Francis Group 2023-12-01
Edice:Prion
Témata:
Collective motions
network analysis
normal mode analysis
Prion protein
structural dynamics
On-line přístup:https://www.tandfonline.com/doi/10.1080/19336896.2023.2186674

Internet

https://www.tandfonline.com/doi/10.1080/19336896.2023.2186674

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