Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma

Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma

Cancer-associated fibroblasts (CAFs) are the dominant component of the tumor microenvironment (TME) that can be beneficial to the generation and progression of cancer cells leading to chemotherapeutic failure via several mechanisms. Nevertheless, the roles of CAFs on anti-cancer drug response need m...

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Bibliographic Details
Main Authors: Yingpinyapat Kittirat, Manida Suksawat, Suyanee Thongchot, Sureerat Padthaisong, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Sakkarn Sangkhamanon, Attapol Titapun, Watcharin Loilome, Hideyuki Saya, Nisana Namwat
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
cholangiocarcinoma
IL-6
gemcitabine
cancer-associated fibroblasts
tocilizumab
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.897368/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.897368/full

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