Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with limited survival rate. Roles for peptidylarginine deiminases (PADs) have been studied in relation to a range of cancers with roles in epigenetic regulation (including histone modification and microRNA regulation)...

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Bibliographic Details
Main Authors: Pinar Uysal-Onganer, Stefania D’Alessio, Maria Mortoglou, Igor Kraev, Sigrun Lange
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
peptidylarginine deiminases (PADs)
protein deimination
extracellular vesicles (EVs)
pancreatic ductal adenocarcinoma (PDAC)
moesin
prohibitin (PHB)
Online Access:https://www.mdpi.com/1422-0067/22/3/1396

Internet

https://www.mdpi.com/1422-0067/22/3/1396

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