People who use drugs show no increase in pre-existing T-cell cross-reactivity toward SARS-CoV-2 but develop a normal polyfunctional T-cell response after standard mRNA vaccination

People who use drugs show no increase in pre-existing T-cell cross-reactivity toward SARS-CoV-2 but develop a normal polyfunctional T-cell response after standard mRNA vaccination

People who use drugs (PWUD) are at a high risk of contracting and developing severe coronavirus disease 2019 (COVID-19) and other infectious diseases due to their lifestyle, comorbidities, and the detrimental effects of opioids on cellular immunity. However, there is limited research on vaccine resp...

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Bibliographic Details
Main Authors: Murat Gainullin, Lorenzo Federico, Julie Røkke Osen, Viktoriia Chaban, Hassen Kared, Amin Alirezaylavasani, Fridtjof Lund-Johansen, Gull Wildendahl, Jon-Aksel Jacobsen, Hina Sarwar Anjum, Richard Stratford, Simen Tennøe, Brandon Malone, Trevor Clancy, John T. Vaage, Kathleen Henriksen, Linda Wüsthoff, Ludvig A. Munthe
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
people who use drugs
SARS-CoV-2 vaccination
T cell responses
T cell subsets
T cell functionality
antiviral immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1235210/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1235210/full

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