Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation

Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation

Chronic kidney disease (CKD) is a kidney structure and function abnormality. CKD development and progression are strongly influenced by oxidative stress and inflammatory responses, which can lead to tubulointerstitial fibrosis. Unfortunately, there are no effective or specific treatments for CKD. We...

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Bibliographic Details
Main Authors: Jeongwon Kim, Jieun Lee, Dahye Yoon, Minjung Son, Mi-Jeong Kim, Sugyeong Ha, Doyeon Kim, Ji-an Yoo, Donghwan Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antioxidants
Subjects:
kidney fibrosis
oxidative stress
inflammation
fibroblast
NF-κB
Online Access:https://www.mdpi.com/2076-3921/12/11/1947

Internet

https://www.mdpi.com/2076-3921/12/11/1947

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