Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice

Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice

CX3C Motif Chemokine Ligand 1 (CX3CL1; fractalkine) has been implicated in the pathogenesis of rheumatoid arthritis (RA) and its inhibition was found to attenuate arthritis in mice as well as in a clinical trial. Therefore, we investigated the effects of an anti-CX3CL1 monoclonal antibody (mAb) on i...

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Bibliographic Details
Main Authors: Satoshi Mizutani, Junko Nishio, Kanoh Kondo, Kaori Motomura, Zento Yamada, Shotaro Masuoka, Soichi Yamada, Sei Muraoka, Naoto Ishii, Yoshikazu Kuboi, Sho Sendo, Tetuo Mikami, Toshio Imai, Toshihiro Nanki
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
rheumatoid arthritis
interstitial lung diseases
CX3CL1/fractalkine
CX3CR1
M1 macrophage
M2 macrophage
Online Access:https://www.mdpi.com/1424-8247/14/5/474

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https://www.mdpi.com/1424-8247/14/5/474

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