Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis

Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis

The identification of a drug that stimulates endogenous myelination and spares axon degeneration during multiple sclerosis (MS) could potentially reduce the rate of disease progression. Using experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, we have previously shown that prophyla...

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Bibliographic Details
Main Authors: Shalini Kumar, Rhusheet Patel, Spencer Moore, Daniel K. Crawford, Nirut Suwanna, Mario Mangiardi, Seema K. Tiwari-Woodruff
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Neurobiology of Disease
Subjects:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Neuroprotective drug
Remyelination
Demyelination
Estrogen receptor ligands
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001198

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http://www.sciencedirect.com/science/article/pii/S0969996113001198

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