Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis

Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis

The identification of a drug that stimulates endogenous myelination and spares axon degeneration during multiple sclerosis (MS) could potentially reduce the rate of disease progression. Using experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, we have previously shown that prophyla...

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Podrobná bibliografie
Hlavní autoři: Shalini Kumar, Rhusheet Patel, Spencer Moore, Daniel K. Crawford, Nirut Suwanna, Mario Mangiardi, Seema K. Tiwari-Woodruff
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2013-08-01
Edice:Neurobiology of Disease
Témata:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Neuroprotective drug
Remyelination
Demyelination
Estrogen receptor ligands
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0969996113001198

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113001198

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