Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis

Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis

Phosphodiesterase-4 (PDE4) functions as a catalyzing enzyme targeting hydrolyzation of intracellular cyclic adenosine monophosphate (cAMP) and inhibition of PDE4 has been proven to be a competitive strategy for dermatological and pulmonary inflammation. However, the pathological role of PDE4 and the...

Full description

Bibliographic Details
Main Authors: Heng Li, Yao Zhang, Moting Liu, Chen Fan, Chunlan Feng, Qiukai Lu, Caigui Xiang, Huimin Lu, Xiaoqian Yang, Bing Wu, Duowu Zou, Wei Tang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ulcerative colitis
PDE4
Mucosal homeostasis
Gut microbiota
Epithelial barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001349

Internet

http://www.sciencedirect.com/science/article/pii/S2211383521001349

Similar Items