Integrated analysis reveals the regulatory mechanism of the neddylation inhibitor MLN4924 on the metabolic dysregulation in rabbit granulosa cells

Integrated analysis reveals the regulatory mechanism of the neddylation inhibitor MLN4924 on the metabolic dysregulation in rabbit granulosa cells

Abstract Background Neddylation, an important post-translational modification (PTM) of proteins, plays a crucial role in follicular development. MLN4924 is a small-molecule inhibitor of the neddylation-activating enzyme (NAE) that regulates various biological processes. However, the regulatory mecha...

Full description

Bibliographic Details
Main Authors: Mengjuan Chen, Yuqing Liu, Mingzhong Zuo, Meina Zhang, Zhitong Wang, Xin Li, Dongdong Yuan, Huifen Xu, Guangqing Yu, Ming Li
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Genomics
Subjects:
Rabbit
MLN4924
Neddylation
Granulosa cells
Transcriptome
Metabolome
Online Access:https://doi.org/10.1186/s12864-024-10118-3

Internet

https://doi.org/10.1186/s12864-024-10118-3

Similar Items