A Deep-Learning Pipeline for TSS Coverage Imputation From Shallow Cell-Free DNA Sequencing

A Deep-Learning Pipeline for TSS Coverage Imputation From Shallow Cell-Free DNA Sequencing

Cell-free DNA (cfDNA) serves as a footprint of the nucleosome occupancy status of transcription start sites (TSSs), and has been subject to wide development for use in noninvasive health monitoring and disease detection. However, the requirement for high sequencing depth limits its clinical use. Her...

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Bibliographic Details
Main Authors: Bo-Wei Han, Xu Yang, Shou-Fang Qu, Zhi-Wei Guo, Li-Min Huang, Kun Li, Guo-Jun Ouyang, Geng-Xi Cai, Wei-Wei Xiao, Rong-Tao Weng, Shun Xu, Jie Huang, Xue-Xi Yang, Ying-Song Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Medicine
Subjects:
cell-free DNA
deep learning
nucleosome footprint
whole-genome sequencing
autoencoder
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.684238/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.684238/full

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