Cyclic-di-GMP Induces STING-Dependent ILC2 to ILC1 Shift During Innate Type 2 Lung Inflammation

Cyclic-di-GMP Induces STING-Dependent ILC2 to ILC1 Shift During Innate Type 2 Lung Inflammation

Type 2 inflammation is found in most forms of asthma, which may co-exist with recurrent viral infections, bacterial colonization, and host cell death. These processes drive the accumulation of intracellular cyclic-di-nucleotides such as cyclic-di-GMP (CDG). Group 2 innate lymphoid cells (ILC2s) are...

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Bibliographic Details
Main Authors: Kellen J. Cavagnero, Jana H. Badrani, Luay H. Naji, Michael B. Amadeo, Anthea S. Leng, Lee Diego Lacasa, Allyssa N. Strohm, Samantha R. Renusch, Suzanna S. Gasparian, Taylor A. Doherty
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
ILC
ILC1
ILC2
asthma
Cyclic-di-GMP
STING
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.618807/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.618807/full

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