Structure-based virtual screening for PDL1 dimerizers: Evaluating generic scoring functions
The interaction between PD1 and its ligand PDL1 has been shown to render tumor cells resistant to apoptosis and promote tumor progression. An innovative mechanism to inhibit the PD1/PDL1 interaction is PDL1 dimerization induced by small-molecule PDL1 binders. Structure-based virtual screening is a p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | Current Research in Structural Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665928X22000198 |