Polyurea Dendrimer Folate-Targeted Nanodelivery of <span style="font-variant: small-caps">l</span>-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

Polyurea Dendrimer Folate-Targeted Nanodelivery of <span style="font-variant: small-caps">l</span>-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

Ovarian cancer is a highly lethal disease, mainly due to chemoresistance. Our previous studies on metabolic remodeling in ovarian cancer have supported that the reliance on glutathione (GSH) bioavailability is a main adaptive metabolic mechanism, also accounting for chemoresistance to conventional t...

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Bibliographic Details
Main Authors: Adriana Cruz, Pedro Mota, Cristiano Ramos, Rita F. Pires, Cindy Mendes, José P. Silva, Sofia C. Nunes, Vasco D. B. Bonifácio, Jacinta Serpa
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Antioxidants
Subjects:
ovarian cancer
chemoresistance
<span style="font-variant: small-caps">l</span>-buthionine sulfoximine
polyurea dendrimers
carboplatin
nanoparticles-mediated chemotherapy
chemosensitization
Online Access:https://www.mdpi.com/2076-3921/9/2/133

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https://www.mdpi.com/2076-3921/9/2/133

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