CXCL12 secreted by pancreatic stellate cells accelerates gemcitabine resistance of pancreatic cancer by enhancing glycolytic reprogramming

Pancreatic stellate cells (PSCs) are the primary cell components of pancreatic cancer (PC) and are involved in tumor growth, metastasis and resistance. However, the role and the mechanism of PSCs in gemcitabine (GEM) resistance to PC still need more investigation. We found that CXCL12 mRNA and secre...

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Bibliographic Details
Main Authors: Xiangyu Lu, Yilei Wu, Rui Cao, Xiaojiong Yu, Jun Gong
Format: Article
Language:English
Published: Taylor & Francis Group 2022-07-01
Series:Animal Cells and Systems
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19768354.2022.2091019