Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis

Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis

This study evaluates the prophylactic effect of the peripherally-selective mu-opioid receptor agonist, loperamide, administered topically in a liposomal gel formulation on pain, inflammation, and disease progression in the adjuvant-induced model of experimental rheumatoid arthritis in female Lewis r...

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Bibliographic Details
Main Authors: Susan Hua, Thilani H. Dias, Debbie-Gai Pepperall, Yuan Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
loperamide
arthritis
opioid
peripheral opioid
inflammation
pain
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00503/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00503/full

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