HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1.

HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1.

High mobility group box 1 (HMGB1) protein is a danger-signaling molecule, known to activate an inflammatory response via TLR4 and RAGE. HMGB1 can be either actively secreted or passively released from damaged alveolar epithelial cells. Previous studies have shown that IL-1β, a critical mediator acut...

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Bibliographic Details
Main Authors: Jean-François Pittet, Hidefumi Koh, Xiaohui Fang, Karen Iles, Sarah Christiaans, Naseem Anjun, Brant M Wagener, Dae Won Park, Jaroslaw W Zmijewski, Michael A Matthay, Jérémie Roux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3655948?pdf=render

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http://europepmc.org/articles/PMC3655948?pdf=render

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