Severe Hypouricemia Impairs Endothelium‐Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo‐Controlled, and Crossover Study

Severe Hypouricemia Impairs Endothelium‐Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo‐Controlled, and Crossover Study

Background Uric acid (UA) is a plasmatic antioxidant that has possible effects on blood pressure. The effects of UA on endothelial function are unclear. We hypothesize that endothelial function is not impaired unless significant UA depletion is achieved through selective xanthine oxidase inhibition...

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Bibliographic Details
Main Authors: Benjamin De Becker, Catherine Coremans, Martin Chaumont, Cédric Delporte, Pierre Van Antwerpen, Thierry Franck, Alexandre Rousseau, Karim Zouaoui Boudjeltia, Pierre Cullus, Philippe van de Borne
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
febuxostat
nitric oxide synthase
rasburicase
renin‐angiotensin‐aldosterone system
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.013130

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https://www.ahajournals.org/doi/10.1161/JAHA.119.013130

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