Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA

Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA

Abstract N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contribute...

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Bibliographic Details
Main Authors: Runjiao Zhang, Yizhou Zhang, Fangzhen Guo, Guannan Huang, Yan Zhao, Bingyu Chen, Chang Wang, Chengran Cui, Yichun Shi, Sha Li, Huixian Cui
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01220-0

Internet

https://doi.org/10.1038/s41420-022-01220-0

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