Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

Members of the Tolloid family of metalloproteinases liberate BMPs from inhibitory complexes to regulate BMP gradient formation during embryonic dorsal-ventral axis patterning. Here, we determine mechanistically how Tolloid activity is regulated by its non-catalytic CUB domains in the Drosophila embr...

Full description

Bibliographic Details
Main Authors: Jennifer Winstanley, Annick Sawala, Clair Baldock, Hilary L Ashe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
BMP
gradient formation
Tolloid
Sog/Chordin
Collagen IV
Online Access:https://elifesciences.org/articles/05508

Internet

https://elifesciences.org/articles/05508

Similar Items