The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a

The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a

The inhibitor cystine knot (ICK) is an unusual three-disulfide architecture in which one of the disulfide bonds bisects a loop formed by the two other disulfide bridges and the intervening sections of the protein backbone. Peptides containing an ICK motif are frequently considered to have high level...

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Bibliographic Details
Main Authors: Volker Herzig, Glenn F. King
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Toxins
Subjects:
inhibitor cystine knot
physicochemical stability
spider toxin
insecticidal toxin
ω-hexatoxin-Hv1a
thermal stability
proteolytic degradation
Online Access:http://www.mdpi.com/2072-6651/7/10/4366

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http://www.mdpi.com/2072-6651/7/10/4366

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