Safety and Optimal Neuroprotection of neu2000 in acute Ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial

Safety and Optimal Neuroprotection of neu2000 in acute Ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial

Abstract Background The potential of neuroprotective agents should be revisited in the era of endovascular thrombectomy (EVT) for acute large-artery occlusion because their preclinical effects have been optimized for ischemia and reperfusion injury. Neu2000, a derivative of sulfasalazine, is a multi...

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Bibliographic Details
Main Authors: Ji Man Hong, Mun Hee Choi, Sung-Il Sohn, Yang-Ha Hwang, Seong Hwan Ahn, Yeong-Bae Lee, Dong-Ick Shin, Ángel Chamorro, Dennis W. Choi, on the behalf of the SONIC investigators
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Trials
Subjects:
Endovascular recanalization
Ischemia and reperfusion
Neuroprotectants
Collateral
Online Access:http://link.springer.com/article/10.1186/s13063-018-2746-9

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http://link.springer.com/article/10.1186/s13063-018-2746-9

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