Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity.

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity.

Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell number is limited. Current conventional culture conditions do not allow muscle stem cells to expand in vitro with their...

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Bibliographic Details
Main Authors: Hiroshi Sakai, Sumiaki Fukuda, Miki Nakamura, Akiyoshi Uezumi, Yu-Taro Noguchi, Takahiko Sato, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Shahragim Tajbakhsh, So-Ichiro Fukada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5428926?pdf=render

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http://europepmc.org/articles/PMC5428926?pdf=render

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