Calcium-Sensing Receptor Antagonist NPS-2143 Inhibits Breast Cancer cell Proliferation, Migration and Invasion via Downregulation of p-ERK1/2, Bcl-2 and Integrin β1 and Induces Caspase 3/7 Activation

Calcium-Sensing Receptor Antagonist NPS-2143 Inhibits Breast Cancer cell Proliferation, Migration and Invasion via Downregulation of p-ERK1/2, Bcl-2 and Integrin β1 and Induces Caspase 3/7 Activation

Purpose: Calcium-sensing receptor (CaSR) has been associated with breast cancer metastasis tothe bone. Targeting chemoattractant factors, such as calcium, that are released in response tobone resorption could prevent metastasis and induce apoptosis of cancer cells. In the presentstudy, we investigat...

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Bibliographic Details
Main Authors: Mohammad A.Y. Alqudah, Marwah Azaizeh, Aref Zayed, Leen Asaad
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
breast cancer
calcium-sensing receptor
nps-2143
caspase 3/7
proliferation
invasion
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-12-383.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-12-383.pdf

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