The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

Skeletal muscle has remarkable adaptive and regenerative capacity. Here the authors show that the transcription factor Prox1 is necessary for maintenance of slow muscle fibre types via activation of NFAT signalling, and for myoblast differentiation via cross-talk with the Notch signalling pathway.

Bibliographic Details
Main Authors: Riikka Kivelä, Ida Salmela, Yen Hoang Nguyen, Tatiana V. Petrova, Heikki A. Koistinen, Zoltan Wiener, Kari Alitalo
Format: Article
Language:English
Published: Nature Portfolio 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13124

Internet

https://doi.org/10.1038/ncomms13124

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