Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

Folate (vitamin B9) is involved in one-carbon transfer reactions and plays a significant role in nucleic acid synthesis and control of cellular proliferation, among other key cellular processes. It is now recognized that the role of folates in different stages of carcinogenesis is complex, and more...

Full description

Bibliographic Details
Main Authors:	Blake R. Rushing, Halle M. Fogle, Jaspreet Sharma, Mikyoung You, Jonathan P. McCormac, Sabrina Molina, Susan Sumner, Natalia I. Krupenko, Sergey A. Krupenko
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Molecules
Subjects:	folate ALDH1L1 cancer metabolomics
Online Access:	https://www.mdpi.com/1420-3049/27/23/8394

Similar Items

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and <i>Aldh1l1</i> Knockout Mice
by: Jaspreet Sharma, et al.
Published: (2022-05-01)

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis
by: Natalia I. Krupenko, et al.
Published: (2021-06-01)

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder
by: Natalia I. Krupenko, et al.
Published: (2020-11-01)

The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1
by: Sergey A. Krupenko, et al.
Published: (2019-10-01)

Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors
by: Ziad Omran
Published: (2022-01-01)

Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis
by: Traci Topping, et al.
Published: (2022-04-01)

Cerebral Folate Metabolism in Post-Mortem Alzheimer’s Disease Tissues: A Small Cohort Study
by: Naila Naz, et al.
Published: (2022-12-01)

Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells
by: Hong-Quan Duong, et al.
Published: (2017-07-01)

A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements
by: Naila Naz, et al.
Published: (2023-01-01)

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors
by: Ali I. M. Ibrahim, et al.
Published: (2021-09-01)

Rektal Adenokarsinomlarda Aldehid Dehidrogenaz 1 ALDH1 ve Gamma Synuclein Ekspresyonunun Prognostik Değeri
by: Özlem Ata, et al.
Published: (2020-12-01)

ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer
by: Tingting Yao, et al.
Published: (2020-09-01)

Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma
by: Bo Zhu, et al.
Published: (2017-04-01)

Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells
by: Michael W. Caminear, et al.
Published: (2022-03-01)

The Immunohistochemical Assessment of ALDH1 Activity in Breast Cancer and it’s Correlation With Pathologic Features
by: Molanae S, et al.
Published: (2011-12-01)

Expression of stem cell biomarker aldehyde dehydrogenase 1 (ALDH1) in canine mammary tumor
by: D S GAVHANE, et al.
Published: (2016-03-01)

Silybin Prevents Prostate Cancer by Inhibited the ALDH1A1 Expression in the Retinol Metabolism Pathway
by: Ying Jiang, et al.
Published: (2020-08-01)

Distribution of Aldh1L1-CreERT2 Recombination in Astrocytes Versus Neural Stem Cells in the Neurogenic Niches of the Adult Mouse Brain
by: Felix Beyer, et al.
Published: (2021-09-01)

Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells
by: Yang Wu, et al.
Published: (2023-10-01)

An antisense Alu transposon insertion/deletion polymorphism of ALDH1A1 may functionally associate with Parkinson’s disease
by: Hui-Hui Fan, et al.
Published: (2022-05-01)

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. “The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer” <i>Cancers</i> 2020, <i>12</i>, 1382
by: Sergey A. Krupenko, et al.
Published: (2021-04-01)

A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer
by: Nkechiyere G. Nwani, et al.
Published: (2019-04-01)

ALDH1A2 Is a Candidate Tumor Suppressor Gene in Ovarian Cancer
by: Jung-A Choi, et al.
Published: (2019-10-01)

ALDH1A1 Inhibits Chicken Preadipocytes’ Proliferation and Differentiation via the PPARγ Pathway In Vitro and In Vivo
by: Jing Zhang, et al.
Published: (2020-04-01)

Chromium (VI)‐induced ALDH1A1/EGF axis promotes lung cancer progression
by: Xin Ge, et al.
Published: (2022-12-01)

Structure of putative tumor suppressor ALDH1L1
by: Yaroslav Tsybovsky, et al.
Published: (2022-01-01)

Aldehyde Dehydrogenase 1 (ALDH1) Promotes the Toxicity of TRAIL in Non-Small Cell Lung Cancer Cells via Post-Transcriptional Regulation of MEK-1 Expression
by: Shuang Tian, et al.
Published: (2018-11-01)

A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
by: Vaishnavi Muralikrishnan, et al.
Published: (2022-07-01)

MiR-23b controls ALDH1A1 expression in cervical cancer stem cells
by: Weiwen Wang, et al.
Published: (2017-04-01)

Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson’s Disease
by: Kathleen Carmichael, et al.
Published: (2021-05-01)

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression
by: Ilias Tsochantaridis, et al.
Published: (2023-01-01)

Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
by: Xinyan Li, et al.
Published: (2021-10-01)

Chromium (VI) promotes lung cancer initiation by activating EGF/ALDH1A1 signalling
by: Anastasia E. Metropulos, et al.
Published: (2022-12-01)

miR-625 reverses multidrug resistance in gastric cancer cells by directly targeting ALDH1A1
by: Gong X, et al.
Published: (2019-07-01)

SIRT5 promotes the proliferation of human breast cancer cells by regulating the succinylation of ALDH5A1
by: KANG You-li, ZHAO Dan, DU Wen-jing, LI Li
Published: (2022-07-01)

ALDH7A1 rs12514417 polymorphism may increase ischemic stroke risk in alcohol-exposed individuals
by: Chun-Hsiang Lin, et al.
Published: (2022-10-01)

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction
by: Michael F. Coleman, et al.
Published: (2021-05-01)

Possible role of ALDH1 and CD44 in lip carcinogenesis
by: Rafael Carneiro ORTIZ, et al.
Published: (2023-12-01)

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors
by: Yaolu Wei, et al.
Published: (2022-10-01)

ALDH5A1 Downregulation Promotes Tumor Metastasis and Contributes to Poor Prognosis in Ovarian Cancer
by: ZHAO Tong, et al.
Published: (2023-02-01)