Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions

Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions

Cryptdin-4 (crp4) is an enteric α-defensin derived from mice, and is a main mediator of immunity to oral infections and a determinant of the composition of the intestinal microbiota. Structurally, crp4 exists in two states: the oxidized form (crp4oxi), constrained by three invariant disulfide bonds,...

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Bibliographic Details
Main Authors: Yi Wang, Yuchi Song, Shaonan Yan, Rina Hiramine, Yuki Ohnishi, Yuki Yokoi, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antibiotics
Subjects:
antimicrobial peptide
defensin
membrane disruption
oxidative stress
<i>Escherichia coli</i>
Online Access:https://www.mdpi.com/2079-6382/12/6/1047

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https://www.mdpi.com/2079-6382/12/6/1047

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