Preoperative Radiotherapy with a Simultaneous Integrated Boost Compared to Chemoradiotherapy for cT3-4 Rectal Cancer: Long-Term Results of a Multicenter Randomized Study

Preoperative Radiotherapy with a Simultaneous Integrated Boost Compared to Chemoradiotherapy for cT3-4 Rectal Cancer: Long-Term Results of a Multicenter Randomized Study

Background: Preoperative chemoradiotherapy (CRT) is the standard treatment for T3-4 rectal cancer. Here, we compared image-guided and intensity-modulated RT (IG-IMRT) with a simultaneous integrated boost (SIB) (instead of concomitant chemotherapy) versus CRT in a multi-centric randomized trial. Meth...

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Bibliographic Details
Main Authors: Benedikt Engels, Antonino De Paoli, Elena Delmastro, Fernando Munoz, Stefano Vagge, Darius Norkus, Hendrik Everaert, Gianna Tabaro, Elisabetta Gariboldi, Umberto Ricardi, Eugenio Borsatti, Pietro Gabriele, Roberto Innocente, Elisa Palazzari, Emilie Dubaere, Marc-André Mahé, Sven Van Laere, Thierry Gevaert, Mark De Ridder
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
rectal cancer
radiation therapy
image-guided and intensity-modulated RT (IG-IMRT)
simultaneous integrated boost (SIB)
chemoradiotherapy (CRT)
randomized clinical trial
Online Access:https://www.mdpi.com/2072-6694/15/15/3869

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https://www.mdpi.com/2072-6694/15/15/3869

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