Uncovering the roles of Mycobacterium tuberculosis melH in redox and bioenergetic homeostasis: implications for antitubercular therapy

Uncovering the roles of Mycobacterium tuberculosis melH in redox and bioenergetic homeostasis: implications for antitubercular therapy

ABSTRACTMycobacterium tuberculosis (Mtb), the pathogenic bacterium that causes tuberculosis, has evolved sophisticated defense mechanisms to counteract the cytotoxicity of reactive oxygen species (ROS) generated within host macrophages during infection. The melH gene in Mtb and Mycobacterium marinum...

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Bibliographic Details
Main Authors: Yu-Ching Chen, Xinxin Yang, Nan Wang, Nicole S. Sampson
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mSphere
Subjects:
Mycobacterium tuberculosis
redox homeostasis
ergothioneine
aldehyde
bioenergetic homeostasis
Online Access:https://journals.asm.org/doi/10.1128/msphere.00061-24

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https://journals.asm.org/doi/10.1128/msphere.00061-24

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