The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts

M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis. The parasite clearance profile after drug treatment in preclinical st...

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Bibliographic Details
Main Authors: Molly Parkyn Schneider, Oliver Looker, Maria Rebelo, David S. Khoury, Matthew W. A. Dixon, Claude Oeuvray, Brendan S. Crabb, James McCarthy, Paul R. Gilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Plasmodium falciparum
protein translation
cytoadherence
protein trafficking
antimalarial compound
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1211613/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1211613/full

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